Evolution-adjusted Tumor Pathophysiology: by Albrecht Reichle

Author:Albrecht Reichle
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

Therapy-relevant action-theoretical approaches may uncover the interwoven modular tumor architecture. This way, we can describe modular textures on a molecular basis, (1) on the background of altered cell functions in the course of rationalization processes, and (2) with novel therapy-guiding ‘universal’ biomarkers (cellular secretome analytics) (Chap. 15).

In each new tumor case a few small regulatory changes may be detectable, sufficing to redeploy rationalization processes, which are robust, adaptable, and which create novel interfaces. By applying novel indirect methodologies (‘intensio obliqua’) for uncovering the architecture of rationalization processes, hubs within rationalization processes, or for identifying deformations and Achilles’ heels in tumor systems, vulnerable nodal points of rationalization processes could be targeted in future with ‘bottom-up’ strategies (Fig. 12.10).

Up to now, the success of cancer screening programmes solely depends on the assumption that small, primary tumors are curable if detected early enough. This field, however, could be further personalized by considering communication derived tumor pathophysiology, particularly rationalization processes (Chap. 15).

An evolution theory allows a possible virtualization of the engagement to get experiences via implementation of non-normative boundary conditions (Pragmatic virtualization of communication acts)

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